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Objectives: Some earlier studies has highlighted the analgesic potentiating effects of intrathecal fentanyl hydrochloride while some recent studies have focused on the effects of decreasing post operative nausea and vomiting . Hence, the current study was planned on comparing the effects of intrathecal fentanyl and intravenous ondansetron in reducing the perioperative nausea and vomiting. Materials and methods: In this randomized prospective study, 140 patients (ASA I&II, aged 18-35 years ) undergoing elective caesarean section were divided into two equal groups (n=70) to receive either intrathecal 20 microgram (0.4ml) with 2.2 ml bupivacaine 0.5% heavy plus 2 ml normal saline intravenously (Group F) or 0.4 ml of normal saline with equal amount of bupivacaine 0.5 % heavy plus 4 mg (2 ml) of ondansetron intravenously (Group O) to compare their effects on perioperative nausea and vomiting . Results: The incidences of intraoperative nausea (12.8% vs 7.15%), vomiting (8.58% vs 4.28%) and retching (8.58% vs 4.28%) were higher in the ondansetron group compared with the fentanyl group and statistically not significant(nausea , P=0.26;vomiting ,P=0.30 and retching , P=0.30). However, the incidence of postoperative nausea , vomiting and retching were higher in the fentanyl group (7.15% vs 2.86%,P=0.25; 4.28vs2.86,P=0.65 and 4.28vs2.86,P=0.65) respectively. Intraoperative and postoperative hemodynamic parameters were comparable in the two groups(P>0.05). Conclusion: Although not statistically significant , the incidences of nausea , vomiting and retching were higher in the ondansetron group intraopertively and the same being higher in the fentanyl group postopertively. Key-words: intravenous ondansetron, intrathecal fentanyl, PONV, caesarean delivery, spinal anaesthesia.

iosr journal of dental and medical sciences

Comparative study of intravenous ondansetron and intrathecal fentanyl for prevention of perioperative nausea and vomiting during caesarean delivery under spinal anaesthesia with hyperbaric bupivacaine.