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Thalassemia syndromes are considered to be the most common genetic disorders worldwide. Hence, prenatal diagnosis using genotyping techniques are designed for the early diagnosis and management. The costs of these prenatal diagnostic techniques as well as confirmatory tests for these thalassemic syndromes are expensive to be made available in poor resourced countries. Hence, screening tests were developed for field diagnosis of these disorders. Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) was designed as a simple screening test for the detection of thalassemic syndromes. In this study, we compared two groups which showed positivity for NESTROFT with the negative test group for all the haematological parameters available by an automated hematology analyzer so as to decide the samples to be tested for NESTROFT in a routine Clinical Pathology Laboratory. Materials and Methods: All the peripheral smears and complete hemograms received in the clinical pathology laboratory during the period of July 2016 to December 2016 were included in the study. Peripheral smear findings and their corresponding haematological parameters were evaluated. NESTROFT was carried out in all the samples and the test results are compared with their corresponding peripheral smear findings and haematological parameters. Results: It was observed that in both the NESTROFT positive and negative test groups, there was no significant difference in the haematological parameters. None of the parameters could be used to narrow down the sample size to be used for NESTROFT screening in the routine clinical pathology laboratory. Conclusion: It is concluded from our study that all peripheral smears with a microcytic hypochromic anaemia especially in women of child bearing age group should be screened for thalassemia trait by using NESTROFT as a routine test in clinical laboratories.

Correlation of Hematological Parameters and NESTROFT in A Routine Hematology Laboratory – A Prospective Study