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Dyspepsia is a common gastrointestinal process that can generate symptoms of heartburn and chest pain. Proton pump inhibitors (PPIs) are the gold standard for the treatment of dyspepsia; however, a substantial group of dyspepsia patients fail to respond to PPIs(Rabeprazole). In the past, it was believed that acid reflux into the esophagus causes all, or at least the majority, of symptoms attributed to dyspepsia, with both erosive esophagitis and nonerosive outcomes. However, with modern testing techniques it has been shown that, in addition to acid reflux, the reflux of nonacid gastric and duodenal contents into the esophagus may also induce dyspepsia symptoms. Here we report 5 cases who were treated on proton pump inhibitors on detailed investigations revealed an alternative cause for dyspepsia. The authors aim to clarify the Pathophysiology, definition, diagnostic techniques and treatment of patients with heartburn symptoms who symptoms of dyspepsia continues even after treatment with PPI (rabeprazole).

Case Series on Persistant Dyspepsia Even After Treatment with Proton Pump Inhibitors