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Many patients present to the surgical department with a thyroid nodule. However not all require surgery and only 5-6% of these are malignant. There are many methods to diagnose and predict malignancy in a thyroid nodule. This study throws light on the usefulness of TSH (thyroid stimulating hormone) estimation and its role in predicting malignancy. This is a prospective study involving 100 patients admitted to our hospital with thyroid swellings suspicious of malignancy. The objective was to evaluate the utility of serum TSH (thyroid stimulating hormone) estimation as a biochemical predictor of malignancy in suspicious thyroid nodules and to study the clinical presentation of thyroid malignancies.The mean preoperative TSH value was 2.39±1.42 mU/L. Mean TSH value in malignancy was higher (3.71±1.22mU/L) compared to those with benign disease (1.80±1.03mU/L).Incidence of malignancy increased with higher TSH values. We concludedin our study the utility of pre-operative serum TSH level as a predictor of malignancy and it showed statistically significant (p <0.01) between higher TSH levelsand malignant nodules. TSH levels could be used as predictor in clinically suspect malignant thyroid swelling with a benign FNAC (fine needle aspiration cytology) report. In such cases where TSH value is high, the FNAC (fine needle aspiration cytology) can be relocked to confirm the diagnosis.

The Utility of Pre operative Serum Thyroid Stimulating Hormone Level For Predicting Malignancy in Nodular Thyroid Disease And Their Clinical Study