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Background:Rocuronium bromide is said to be devoid of the adverse effects that are seen with suxamethonium. Its mechanism of action is competitive non-depolarizing neuromuscular block with high degree of selectivity for post-nicotinic cholinergic receptors of skeletal muscle. The most important advantages of rocuronium are the rapid onset and good to excellent intubating conditions within 60-90 seconds after administration of 0.6 mg/kg dose. The speeds of onset of neuromuscular blocking drug are increased by prior administration of magnesium sulphate. MgSO4 administered before intubation provides better intubating conditions and intraoperative haemodynamic stability. Methods: A total of 50 patients were selected randomly from the routine operation lists for the study. All patients were ASA grade I &II between age group of 18 to 60 years of either sex. The patients were divided in to two groups of twenty five each. Group I (MgSO4 Group)Patients were given MgSO4 60 mg/kg diluted in normal saline making it total 100 ml as an intravenous infusion. Group II (Control Group)Patients were given 100 ml normal saline as an intravenous infusion. Results:Results demonstrated that onset time in group I was 85.84 ± 17.83 seconds (mean ± S.D) and in group II it was 89.2 ± 20.70 seconds. The differences in mean onset time between groups were not statistically significant (P==0.5415, P> 0.05).Furthermore, clinical duration in group I was 45.92 ± 8.80 minutes and in group II it was 25.36 ± 4.28 minutes . The differences in mean clinical duration between groups were statistically highly significant (P=0.0001, P< 0.05). Mean clinical duration was significantly prolonged in group I than in group II. Thus, prior administration of MgSO4 (60 mg/kg) did not increase speed of onset, but prolonged duration of action of rocuronium induced (0.6 mg/kg) neuromuscular block. Conclusion:MgSO4 did not increase the speed of onset time, but prolonged the clinical duration of rocuroniuminduced neuromuscular block. Also, MgSO4 administered before intubation provides better intubating conditions and intraoperative haemodynamic stability.

Effect of Magnesium Sulphate on the Speed of Onset and Duration of Neuromuscular Block Produced by Rocuronium Bromide