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Background: In India, etiology of cirrhosis varies with geographical areas. Aim: To evaluate etiological and clinical spectrum of cirrhosis in eastern Madhya Pradesh state of India. Methods: The study includes 125 cirrhotic patients (aged >14yrs) diagnosed by clinical, biochemical and radiological parameters admitted in NSCB medical college, Jabalpur between 2009 and 2011. All patients underwent routine lab investigations, and tests for hepatitis B and hepatitis C virus. Tests for Autoimmune, Wilson’s disease and Haemochromatosis were also done. Patients were treated and outcome was noted. Results: Mean age was 52 ± 10 Years, male constituted 71.2% cases. Alcoholism was seen in 36.8%, HBV in 36.8% and HCV in 3.2% cases. Wilson’s disease, cardiac cirrhosis was seen in 1(0.8%) patient each. No etiology could be found in 20.8% patients. Commonest presentation was ascites in (84.8%), followed by jaundice (60%), gastro-intestinal bleed (38.4%), Hepatic encephalopathy (18.4%), Hepatorenal syndrome (12%) and Spontaneous Bacterial peritonitis (4.0%). Maximum patients were in Child’s Pugh B class (49%). Main cause of mortality was HE and HRS; maximum deaths occurred in Child’s C. Conclusion: Alcohol and HBV were major etiologies. Most common presentation was ascites and jaundice and maximum mortality was seen in Child’s C.

Spectrum of Cirrhosis of Liver in Eastern Madhya Pradesh, India