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Sickle cell anaemia is a genetic disorder characterized by chronic haemolytic state. Defective lipid in sickle cell anaemia has been attributed to increased cholesterol utilization consequent to increased erythropoiesis. Anthropometric measurements can easily reflect changes in the lipid deposition in the human body This study aimed at correlating lipid profile and anthropometric parameters in Nigerian adults with SCA in steady state. Method: The study is a cross sectional. A total of 58 homozygous haemoglobin SS (Hb SS) patients recruited from haematologyday ward of Obafemi Awolowo University Teaching Hospital Ile –Ife and 25 age and sexmatchedHb AA controls, selected from hospital workers, students and other members of the community were studied. Total cholesterol (TC), High density lipoproteins (HDL), Low density lipoproteins (LDL), triglycerides and non-HDL-cholesterol were measured using Cholestech LDX (Cholestech Corporation U.S.A) from a single drop of capillary (35μ1) blood after an overnight fasting (9-l2hrs). Nutritional Assessment was measured with the aid of tape rule (for length and circumferences) while the skin fold thickness were measured using Caliper and weighing balance for weight. Data was analysed using excel and SPSS (version 20) statistical package. Result: The study showed significant reduction in TC, LDL-c and HDL-c in patients compared with controls while there was no variation in TG in both patients and controls. However,about 57.9% of SCA patients had normal levels of total cholesterol. There was strong correlation between the waist circumference and TC, LDLc and triglyceride in sickle cell patients but not in control. Hip circumference correlated weakly with total cholesterol but strongly with triglyceride and LDL-c, Abdominal skin fold thickness (ABDSFT) correlated weakly with TG and LDL-c while mid thigh circumference (MTC) correlated weakly with LDLc. Conclusion: The anthropometric parameters correlated positively with total cholesterol and non-HDL cholesterol (LDL-c and triglyceride) in sickle cell anaemia Measuring of Waist circumference as well as Hip circumference(less strongly) may be surrogate markers for TC, LDL-c, and triglyceride in sickle cell anaemia

Correlates of Steady State Lipid Profile and Anthropometric Parameters in Adult Sickle Cell Anaemia Patients in South-West Nigeria