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Stroke or cerebrovascular accident is a major public health problem in India .stroke presents as an emergency clinical situation. The risk factors of stroke are hypertension, diabetes mellitus, dyslipidemia, smoking etc,. the association between lipoprotein (a) and cardiovascular mortality is well established. This study establishes stroke severity in relation to lipoprotein (a). Objective: To determine the association of serum levels of liporotein(a) association of stroke severity in stroke patients admitted in Government Stanley Medical College, Chennai. Meterials And Methods: Fifty adult patients presenting with acute ischemic stroke, occurring within 24 hours, confirmed by CT scan admitted in Government Stanley Medical College and hospital, Chennai from June 2012 to December 2012 were included in this study and each patient fasting serum lipoprotein(a) levels were estimated. Results: The total number of patients included in this study was 50. There were 26 male patients and 24 female patients. The correlation coefficient were 0.069 in the negative range. Slight negative correlation exists among the female subjects between lipoprotein level and stroke severity. The statistical significance exists but not large enough in females,it needs further evaluation.The correlation coefficient in the age group below 60 years was studied. Among the male patients studied there exists no correlation. But in the female patients the Lipoprotein(a) measurement has negative correlation with the correlation coefficient being –0.212.When the serum Lp(a) level is correlated with the stroke severity, the mean among the patients with moderate score is 120±82.03 and the mean with severe score is 107.33±74.6.On analysing the above samples the association with Lp(a) with male patients the mean values in the moderate score group is 103.7+/-67.8 and 91.05+/64.95. The mean elevations once again correlates in the moderate score group among the male patients Conclusion: In my study great care is taken to exclude the possible confounding factors like diabetes mellitus patient, renal failure patients, liver failure etc but the role of other risk factors like smoking ,obesity and also the circulating concentration of fibrinogen along with genetic and environmental could not be definitely excluded. Despite these limitations, the presence of statistical significance of lipoprotein(a) associations with stroke severity in men of below 50 years age group opens a new scope for future research.

A Study on Association of Serum Levels of Lipoprotein(A)And Stroke Severity