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Objective: Best fluid regime in burn resuscitation is debatable. Recent evidence supports the use of colloids. This study analyzes the effectiveness of Brooke formula. Method: Brooke formula was used exclusively over 2.5 years. Patients were followed up until discharge. Results were compared with another unit of the same institution that used Parkland formula. Overall mortality as well as the mortality and morbidity within first 72 hours of a highly selected group of patients without adverse prognostic factors were analysed. All adult patients above 15 years of age admitted with burns more than 15% were recruited. Patients with burns less than 40% and age below 60 years without co-morbid factors were included in the highly selected group. Adequacy of resuscitation was assessed by urine output. Oliguric patients received extra amounts of fluid and renal dose dopamine. Main outcome measures were mortality and anuria. Mortality was assessed under two categories; during the first 72 hours of a highly selected group of patients and overall mortality of the unit. Results: Sample size was 42. Twenty-eight patients had favourable prognostic factors. Overall mortality before discharge from hospital was 24%. In total, 68% developed urine output less than 30ml/h. There were no deaths in the highly selected group within the first 72 hours. When mortality was compared with the mortality of the comparable unit the difference was not statistically significant: (P-value = 0.4467), Odds ratio 1.66 (CI 1.00 to 2.73). Except in the case of patients who died, the patients who developed oliguria recovered without going into anuria when dopamine was started together with increasing fluid infusion rate. Conclusion: Brooke formula is an effective alternative to Parkland formula. Nevertheless, urine output has to be monitored judiciously and treated accordingly. Dopamine may have a place to maintain urine output in burns.

Evaluation of Brooke Formula Plus Dopamine in Burn Resuscitation