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A randomized placebo controlled single blind study was conducted to compare the effects of bolus doses of metoprolol and esmolol heart rate ,systolic blood pressure and rate pressure product during laryngoscopy and intubation.60 patients of ASA I and II randomly received placebo or study group(1 mg/kg of esmolol) or 80 μg/kg of metoprolol in 20 ml normal saline.Heart rate,systolic b.p were recorded serially after study drug , before induction,during laryngoscopy and intubation and1/2min,1min,11/2 min ,2 min each minute till parameters reach baseline or 20 minutes whichever is earlier. Rate pressure product was calculated and statistically evaluated in all 3 groups.Statistically significant fall in heart rate blood pressure and rate pressure product obtained in group II and III compared to control. While comparing between study drugs esmolol appears better attenuator of peak rise of blood pressure and metoprolol appears better attenuator of heart rate.Rate pressure product never reached above 15000 in any group at which myocardial ischemia may set in.

iosr journal of dental and medical sciences

Comparison of Effect of IV Esmolol and I.V. Metoprolol For Attenuation of Pressor Response to Laryngoscopy And Intubation During Elective General Surgical Procedures Under General Anaesthesia