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Aim: To compare of the efficacy and safety of prophylactic bolus doses of intravenous Phenylephrine, Ephedrine, and Mephentermine for maintenance of arterial pressure during spinal anesthesia in caesarean section and their effects on neonate. Settings and Design: The present Prospective Randomized study was carried out in a tertiary care teaching hospital. A total of 90 pregnant women posted for elective caesarean section under spinal anesthesia were enrolled and randomly divided into three groups. Group P (phenylephrine) Group E (ephedrine) Group M (mephentermine) with 30 patients in each group. Materials and Methods: Group E received prophylactic bolus of ephedrine 6 mg IV, group M 6 mg IV mephentermine and group P 100 mcg IV of phenylephrine at the time of subarachnoid block. Hemodynamic variables like blood pressure and heart rate were recorded every 2 minutes up to delivery of baby and then every 5 minutes. Neonatal outcome was assessed using Apgar score at 1 and 5 minutes and neonatal umbilical cord blood pH values. Statistical Analysis Used: Comparitibility of groups are analyzed with analysis variance test to analyzed parametric data ‘P’ value < 0.05 was considered significant. Results: There was no difference found in managing hypotension between three groups. The differences in umbilical cord pH and Apgar score between three groups were found statistically insignificant. Conclusion: All the three vasopressors were equally effective in maintaining maternal blood pressure when given prophylactically IV bolus at the time of SAB, without any detrimental effects on fetal and maternal outcome though phenylephrine has quicker peak effect in comparison.

iosr journal of dental and medical sciences

Comparison Between Phenylephrine, Ephedrine And Mephentermine In Preventing Hypotension During Spinal Anesthesia For Caesarean Section And Their Effect On Fetal Outcome.