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The last two decades have seen a significant rise in infections caused by Candida species in various clinical conditions. Candida albicans is the most frequently isolated yeasts in clinical laboratory , but now there is a predominant rise in infections caused by non-albicans Candida.. Differentiating among Candida species in laboratory is very important because of the differences in the virulence of the species and in their susceptibility to anti-fungal drugs. Aims And Objective: The aim of the present study is to isolate and speciate Candida spp. from various clinical specimens, processed in our laboratory and to detect their antifungal susceptibility pattern. Materials And Methods: The study was carried out in The Department of Microbiology, R.G.Kar Medical College and Hospital, Kolkata for the period of 1 yr. A Total 92 Candida isolates were obtained from various clinical samples were included in the study. The isolates were identified up to species level by standard mycological procedure. Antifungal susceptibility testing of the yeast isolates were assessed by Kirby Bauer disc diffusion method following CLSI guidelines M 44A against Amphotericin B and Azole group of antifungals like Fluconazole, ketoconazole, Itraconazole, and Voriconazole. Result: In the study, total 10 species of Candida were isolated from various clinical samples, of which Candida tropicalis was the commonest species isolated 30 (32.6%).The highest number of Candida isolates were obtained from Blood-29 (31.52%).Among the five antifungal drugs tested (Amphotericin B, Ketoconazole, Fluconazole, Itraconazole and Voriconazole), maximum resistance was seen with Fluconazole (29%). Fluconazole resistant was more in NAC species than Candida albicans. Conclusion: Early speciation of Candida isolates along with their antifungal susceptibility tests not only will restrict the empirical use of the antifungal agents but also greatly influence the treatment options for the clinicians and thus optimum benefit of the patients can be achieved.

“Emergence of Non albicans Candida as potential pathogen --- Change in spectrum poses therapeutic challenge”