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Splenic marginal zone lymphoma(SMZL) is a rare B-cell neoplasm comprising less than 2% of lymphoid neoplasms ,composed of small lymphocytes which surround and replace the splenic white pulp ,germinal centres,follicle mantle and merge with marginal zone.We report a case of SMZL in a 40 year old male patient presenting with complaints of low grade fever and left sided abdominal discomfort for 6 months and was noted to have massive splenomegaly on physical examination. Laboratory evaluation revealed leucocytosis and presence of atypical lymphocytes which were larger than mature lymphocytes having moderately basophilic cytoplasm with cytoplasmic processes at the poles of the cell with round to oval nucleus with clumped chromatin and indistinct nucleoli.Immunophenotypic analysis revealed a B-cell population with CD -20 positivity.

Splenic Marginal Zone Lymphoma: A Case Report with Review of Literature Running Title: A Rare Case Report On Splenic Marginal Zone Lymphoma