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Background: Etomidate is the preferred induction agent in patient with Cardiac disease due to its cardiac vascular stability. It can cause severe pain during IV administration which can produce increased stress response. Various methods have been tried to reduce the pain of etomidate injection with variable success. Lignocaine pre-treatment which is extensively used to reduce the pain of propofol injection is also used to reduce the pain of etomidate injection. Materials And Methods: This nonrandomised double blind, study was done after getting ethical clearance from university ethical committee. After informed consent 40 patients of both sexes aged between 18 to 65 years of ASA physical status 1, 2 & 3, who were posted for various elective surgical procedure planned under general anaesthesia were enrolled for the study.. They were not given any premedication. On arriving to Operating room (OR) 20G IV cannula inserted on dorsum of both hands and both flushed with100ml of normal saline. Venous drainage was occluded with elastic band in the both hands at midarm. In one hand 2ml of 1% lignocaine followed by 1 ml (2 mg ) of Etomidate is Injected and pain is assessed by Verbal rating scale(VRS). After one minute in other hand 2 ml (8mg) ondansetron injected followed by 1 ml (2 mg ) of Etomidate and pain is assessed. Statistical analysis: Non-Parametric test-Wilcoxon Sign Ranks Test is used to compare both drugs .Analysis is perfomed using SPSS Version22. Results: A total number of 40 patients (male=57.50%, female=42.50%).The mean age of patient was 42.85, The mean VRS pain score of etomidate after pre-administration of intravenous lignocaine (Drug A) was 1.58, which was lower compared to pre-administration of ondansetron(Drug )2.43. Conclusion: This study illustrates that pre-treatment with intravenous lignocaine significantly reduces the pain on injection of etomidate compare to ondansetron. (P value<0.001).

Comparison of pre treatment with Ondansetron and Lignocaine over Pain on Etomidate Injection. A double blind prospective non randomised study