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Background: Platelet-rich fibrin (PRF) is a platelet concentrate widely used to accelerate soft and hard tissue healing, whereas bioactive glass, an alloplastic bone graft, elicits a specific biological response, resulting in the formation of a bond between the tissues and graft thus facilitating bone healing. Thus, the purpose of this clinical study was to determine the efficacy of PRF and Perioglas ® , as a regenerative material in the treatment of three wall vertical defects. Material and methods: Twenty patients diagnosed with generalized chronic periodontitis having two or more, three wall vertical defects were selected for the study. Clinical parameters like Probing pocket depth (PPD) and relative attachment level (RAL), radiographic evaluation including the depth of the bone defect and the percentage of bone defect fill, were recorded for both the groups at baseline, three and six months. The sites were randomly treated either with PRF or Perioglas ® after debridement. Results: Evaluation of the PRF and Perioglas ® sites from baseline to 6 months revealed that PPD reduced by 4.2 mm(72.4%) and 1.5 mm (21.74%) respectively; RAL reduced from 4.3 mm (32.58%) and 1.5 mm (11.9 %) , respectively; bone fill level from baseline to 6 months revealed a gain of 1.57±43 (25.5%) and 2.06 mm(33.1%), respectively. Conclusion: At the end of six months PPD reduction and RAL gain were greater by PRF than Perioglas ® . However, statistically significant difference in the bone fill of defects was not evidenced among the two groups.

iosr journal of dental and medical sciences

Perioglas® And Prf As Graft Materials in The Treatment of Intrabony Defects in Chronic Generalized Periodontitis: A Clinical And Radiological Evaluation