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OBJECTIVE: The aim of the study is to access the prognostic significance of serum uric acid levels in patients with congestive cardiac failure and its correlation with ejection fraction. MATERIALS AND METHODS: This study was performed in Department of Medicine, Coimbatore Medical College Hospital, Coimbatore. Serum uric acid levels were measured in 100 heart failure patients and their levels were correlated with ejection fraction and NYHA functional class for heart failure. Hemodynamic characteristics and risk factors of the patients were also assessed. Patients were followed up for 30 days with end points of cardiac death or rehospitalisation. RESULTS: Out of 100 patients analysed, 73 patients had higher uric acid levels and 27 had normal uric acid levels. Serum uric acid levels correlated negatively with ejection fraction and positively with NYHA functional class, thus predicting the prognosis and severity in heart failure patients. Patients with higher uric acid levels were in severe heart failure and required significantly more rehospitalisation and had more deaths compared to those with normal uric acid levels. CONCLUSION: Higher serum uric acid levels is a prognostic predictor in patients with congestive cardiac failure. Monitoring of serum uric acid levels may be useful for the management of patients with congestive cardiac failure.

Prognostic Significance of Serum Uric Acid Levels in Congestive Cardiac Failure And Its Correlation With Ejection Fraction