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Background: Detailed knowledge about specific metabolic pathways and molecular mechanisms involved in the development and pathogenesis of prostate disorders are still incomplete.To decide the presence or absence of disease, a cut-off point is chosen for data interpretation. In the current work, we reported the preliminary reference values for panel of biomarkers from healthy Nigerians to aid diagnosis of prostate disorders. Methods: Whole blood was collected from 399 healthy Nigerians men between the ages of 30-70 years. Serum sarcosine, testosterone, and various derivatives of PSA were evaluated using standard procedures. Results: Our results showed that, in between the age bracket of 30-40 years (lowest) , serum sarcosine value range was 54.57-77.55 ng/dl , total testosterone 3.76-8.00 ng/ml, free testosterone 7.13-16.33 ng/ml, total PSA 0.6-4.48 ng/ml, free PSA 0.30-1.09 ng/ml, complex PSA 0.4-3.92 ng/ml ,% free PSA 18.90-39.90, % complex PSA 57.10-84.10. In between the age bracket of 60-70 years (highest) serum sarcosine value ranges 44.8477.26 ng/dl, total testosterone 3.68-5.12 ng/ml, free testosterone 5.82-11.84 ng/ml, total PSA 1.97-3.66 ng/ml, free PSA 1.97-3.66 ng/ml, complex PSA 1.22-2.88 ng/ml, % free PSA 14.65-37.13, % complex PSA 63.71-85.35. Conclusion: This is first of such study to establish reference values for these biomarkers of prostate disorders hence underscored the need to establish reference values for different populations.

Preliminary Reference Values of Serum Sarcosine, Prostate Specific Antigens And Testosterone in Apparently Healthy Males in Sokoto, Nigeria.