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A better understanding of benign breast disorders comes from a comprehensive framework ‘Aberrations of normal development and Involution’ (ANDI) – under which most of the breast complaints can be explained. Benign Breast disorders can be noted as ‘Universal phenomenon’ in all ages of women causing physical and psychological distress to the patient. ANDI is an umbrella term used to describe the breast disorders that arise due to minor aberrations of the normal process of development, cyclical hormonal response and Involution. Though there have been many drugs used previously, their side-effects overwhelmed the benefits. So, a drug with minimal side-effects and maximum efficacy is the need of the hour in relieving the symptoms and promoting regression of ANDI.This has encouraged this study of efficacy of a newer selective estrogen receptor modulator in ANDI. Our study claims that Ormeloxifen is significantly effective in Aberration of development and cyclical changes of Breast with targeted efficacy profile, fewer adverse effects and lower economical burden, but efficacy is not proved in Aberrations of involution of breast.

A Prospective Study of Efficacy of Selective Estrogen Receptor Modulator (Serm) In Aberration of Normal Development and Involution of Breast (Andi)