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Background: Studies have indicated the role of gonadal hormones in regulating structure and function of nearly every tissue and organ in the mammalian body,causing gender differences in a variety of characteristics. Objective of our study is to compare the gender differences in liver function tests in healthy individuals and to find the correlation between bilirubin and other liver markers. Methodology: The retrospective study was conducted by collecting the data from the Clinical Biochemistry Laboratory. Liver function tests were compared among 35 women and 35 men, who got their liver function tests done as a part of routine investigation panel.Comparison of liver parameters were done using independent Student’s ‘T’ test.Correaltion study was done by calculating Pearson’s correlation coefficient. Results: Total and direct bilirubin were very significantly high in males as compared to females ( P=0.002 and P=0.001).We found a significantly high AST (P=0.039) and albumin (P=0.034) in males.AST was positively very highly significantly ( P<0.0001) correlated with total and direct bilirubin (r=0.56 and r=0.7149 respectively). Conclusion:We observed a significantly low total and direct bilirubin, AST and albumin levels in women compared to men. The causative factor is inconclusive and association of liver profile and female gonadal hormones needs further research.

Gender Differences in Liver Function Tests in Coastal Karnataka