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Background: Endotracheal Intubation involving conventional laryngoscopy elicits a hemodynamic response associated with increased heart rate and blood pressure. This is dangerous in patients with compromised cardiac disease which are coming for open heart surgeries. Up till now many drugs have been studied for attenuation of intubation response that too in Ischemic heart disease patients but very few studies are there in literature regarding valvular heart disease surgical patients. Hence we aimed to study comparative effect of intravenous fentanyl Vs Dexmeditomidine for attenuation of cardiovascular response to intubation in adult cardiac surgical patients. Methods: After ethical committee clearance sixty adult patients undergoing open heart surgeries were divided into two groups D and F. Group F: Patient receiving Injection Fentanyl 2 mcg/kg intravenous bolus. Group D: Patient receiving Injection. Dexmedetomidine 0.5mcg /kg for 10 min as infusion. All hemodynamic parameters like Heart rate, Systolic, diastolic and mean blood pressure, SPO2 were measured at intervals. Results: After drug administration HR, SBP, DBP was more in fentanyl group and was statistically significant as compared to Dexmeditomidine group. Conclusion: It is observed that Dexmedetomidine is superior drug even at 0.5μg/kg intravenous as compared to 2 μg/kg fentanyl intravenous

iosr journal of dental and medical sciences

A Prospective Randomized Study of Comparison of Intravenous Fentanyl Vs Intravenous Dexmedetomidine for Attenuation of Cardiovascular Response during Laryngos copy and Tracheal Intubation in Adult Cardiac Surgery.