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Background: Human Immunodeficiency Virus (HIV) is a global phenomenon with an estimated population of 7.7% infected people in Plateau state, Nigeria. Aim: This study was aimed at monitoring the effectiveness of Anti-retroviral Therapy (ART) on HIV-1 infected patients. Procedure: A total number of 109 experimental volunteers’ from Our Lady of Apostle (OLA) hospital, Jos, Nigeria were screened and detailed records were collected using a semi structured questionnaire for a period of 24 months at six months intervals. The effectiveness of ART was monitored using CD4 count and viral loads of the volunteers. Samples were collected in EDTA containers and the baseline CD4 and viral load were estimated. With high viral load (≥400 copies/ml) and low CD4 count (≤200 cells/mm 3 ), the volunteers were made to commence ART treatments based on their low immunity. The CD4 count and the viral load values of the volunteers were then assessed at 6th, 12th, 18th and 24th month intervals. Result: Significant improvement was recorded in CD4 and viral load values of the volunteers; thus leading to an overall improvement in their physical health status and productivity. The active age groups (20 – 49 years) had a collective prevalence rate of 92.66% of the total study population. The highest percentage adherence of 84% was recorded in 40 – 49 years old volunteers. The patients between 50 – 59 years had a 4.59 % prevalence, while those at the two extremities of life had a combined prevalence of 2.75%. The positive response to ART improved steadily throughout the period of the study with an overall adherence rate of 84%. Conclusion: The use of Anti-retroviral Therapy (ART) in the treatment of patients with HIV-1 infection proved to be effective among patients attending OLA hospital, Jos. It should be further encouraged and well advocated in the treatment and management of patient’s with HIV-1 infection.

Effectiveness of Anti-retroviral Therapy (ART) on HIV-1 Patients Using Viral Load and CD4 Counts as Indices