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The observational study is done to find out the frequency of gall bladder cancer in patients of gall bladder disease, found preoperatively or incidentally on biopsy of cholecystectomy specimen. Methodology: The study was carried in surgery ward-6 of Guru Nanak Dev hospital attached to Govt. Medical College Amritsar in which 200 patients of gall bladder disease were studied and relative frequency of gall bladder cancer was noted. Results: In our study, 200 patients of gall bladder disease during a period of 2 years were included. Out of these,20 patients were male while 180 were female. Maximum no of patients reported with Gall Bladder Disease were in age group 31-40 years. 7 patients out of 200 were diagnosed with carcinoma gall bladder,in which 6 were female and 1 was male with majority of patients presenting in the age group 61-70 years. Gall Bladder cancer constituted 8.2% of all Cancers in the body and 50% of all Gastrointestinal Tract cancers.3 patients out of 7 diagnosed with Gall Bladder Cancer were diagnosed preoperatively and rest 4 were diagnosed incidentally on histopathological examination of biopsy specimen of gall bladder. Conclusions: The frequency of Gall Bladder Cancer in our study is 3.5%, with females out numbering males with F/M ratio 6:1 and most of them presenting in the 5 th and 6 th decade of life. Gall Bladder Cancer was strongly associated with gall stones (100%). Gall Bladder Cancer is the most common Gastrointestinal tract cancer.Most of the patients (57%) presented with incidental diagnosis on HPE post cholecystectomy. 43% patients diagnosed preoperatively, were given neoadjuvent chemotherapy. Keywords: Gall bladder,Cacer,Cholecystectomy,Gastrointestinal cancer,undifferentiated cancer

An observational study to find out the frequency of Gall Bladder Cancer in patients of gall bladder disease