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Objectives: To compare the efficacy of bisoprolol and atenolol in hypertension, myocardial infarction and effect on lipid levels. Materials and methods: 18 patients whose blood pressure was above 95mm Hg (Diastolic) or higher were recruited from hypertension clinic. They were given either A or B alternatively. B.P.were recorded both supine and standing position at 30 minutes interval after 2 weeks again B.P. was recorded. In the same way 14 patients were recruited for myocardial infarction. Before giving the drug E,C.G. and blood for lipid profile were taken. After 4weeks again the same procedure were repeated. Results were tabulated and comparison and significance were tested by unpaired students‘t’ test and their ‘p’ value was calculated. Results were also shown graphically. Results Bisoprolol had consistently significant effect than atenolol in hypertension,myocardial infarction and in reducing lipid profile levels. Summary and conclusion: In this double blind study, bisoprolol had consistently greater antihypertensive effect than atenolol(p<0.05>0.02) in supine and in standing (p<0.01>0.001).In Myocardial infarction ,bisoprolol worked more quickly than atenolol.Bisoprolol statistically significant in reducing blood triglycerides and LDL levels. So the efficacy of Bisoprolol is more both in hypertension and in myocardial infarction.

Double Blind Study of Bisoprolol and Atenolol in Hypertension and Myocardial Infarction in Human Subjects