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Background: Gestational hypertension is defined as hypertension arising after mid-pregnancy and is distinguished from preeclampsia by the absence of proteinuria. Some of the women with gestational hypertension progress to preeclampsia. Preeclampsia is associated with increased oxidative stress which is known to be one of the main pathological mechanisms responsible for the mortality and morbidity associated with the condition. Proteinuria though not essential for the diagnosis of preeclampsia, is the common clinical and diagnostic feature of the disorder in women with hypertension. Hypoalbuminemia is common in pregnant women with preeclampsia but the impact of hypoalbuminemia on maternal and fetal morbidity in preeclampsia is not as yet well known. Objectives: The study was designed to assess the serum levels of copper, ceruloplasmin, total proteins and albumin in gestational hypertension. Methods: The study comprising of 50 healthy nonpregnant women, 50 healthy pregnant women and 50 women with gestational hypertension matched for age were assessed for serum ceruloplasmin, copper, total proteins and albumin. Results: An increase in serum levels of copper and ceruloplasmin and decrease in total proteins and albumin in both pregnancy and gestational hypertension cases was observed compared to nonpregnant controls. Conclusion: It was concluded from the present study that there is an increase in copper and ceruloplasmin and decrease in total proteins and albumin in both healthy pregnant and gestational hypertension cases but more pronounced in the latter.

Assessment of Copper, Ceruloplasmin, Total Proteins and Albumin in Gestational Hypertension