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The materials used for obturation of root canal system may get extruded through apical foramen into the per apical tissue. Therefore, biocompatibility of these materials is very important. The purpose of this study was to evaluate the in vivo biocompatibility of three endodontic sealers: Sealapex, Diaket and Tubliseal after their subcutaneous implantation in rats. Each of the materials was injected subcutaneously in the dorsal connective tissue of 20 Wistar albino rats. Tissue biopsies were collected at first day, fifth day, tenth day and thirtieth day after the procedure. The specimens were processed and stained with hematoxylin and eosin and examined microscopically. According to this study, all of the sealers cause inflammatory reactions immediately after contact with tissue, but the intensity of these responses decrease with time. The acute inflammatory responses of initial days changed to chronic proliferative, phase and later to healing processes by the end of one month.

Histopathologic Evaluation of the Subcutaneous Tissue Response toThree Endodontic Sealers