English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background: Current medical needs dictate that laboratories offer thyrotropin (TSH) assays that can reliably measure low TSH. The protocol for determining the functional sensitivity of TSH assays specifies analyses of serum samples with two reagent lots over a 6to 8-week period. Methods: Accordingly, the objective of this study was to evaluate the efficacy of two TSH ELISA assay methods. Sensitivity was evaluated by comparing the level of TSH hormone by testing a range of human serum samples with at least 2 reagent lots for each method. Results: Both ELISA methods were able to detect hormone levels in the sera, but detection was very significantly (t test, P<0.05) greater with the biotinstreptavidin ELISA in sera from human serum samples than in the peroxidase ELISA. The sensitivity of the biotinstreptavidin ELISA was further enhanced by redefining the calibration curve pattern characteristics, using low end calibrators. With the usage of several statistical considerations (regression analysis) and mathematical curve fitting models lower levels of TSH hormone could be successfully evaluated for early hyperthyroid case detection. Conclusion: Second generation TSH assays can be modified for lower detection sensitivity by redefining calibration curve pattern characteristics, using low end calibrators.

Comperative study of biotin, streptovidin -ELISA and peroxidase - ELISA for the estimation of TSH in thyroid diseases