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Purpose: Drug resistance is a burning issue in bacterial kingdom and in appropriate use of antibiotics is one of the most important factors that could affect the increasing patterns of resistance. The aim of the present study is to ascertain the current situation of growing antibiotic resistance against bacteria, ex-gram positive cluster forming cocci. Materials and Methods: Various clinical samples such as pus, sputum, throat swab, high vaginal fluid, prosthetic swab, wound swab, ear swab were taken from776 subjects and cultured on nutrient agar and Mac Conkey's agar. After morphological identification 271 isolates were tested for antimicrobial susceptibility testing. Results: In this study, Antibiotic susceptibility testing was done by using 271 patients sample out of 363 positive growth culture which was collected from pus. It stated that male and female ratio for infection was 1:0.6 and resistance are high in the age group 21-40 years. Observation of susceptibility test indicate that ampicillin,amoxycillin and co-trimoxazole showed increase rate of resistance which were 28, 21 and 15% respectively. On the other hand, cefuroxime and ceftriaxone showed significantly sensitive which belongs to cephalosporin second and third generation group. Conclusion: It is very important to reduce frequent misuse; inadequate dosages and easy availability of antimicrobials to keep away human generation from emerge of antibiotic resistance.

Prevalence of Antimicrobial Sensitivity and resistant Pattern of Gram Positive Cluster Forming Cocci in Clinical Samples