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Background: Intra abdominal pathologies requiring surgical intervention include appendicitis , malignancies, trauma ,perforation peritonitis etc. The most common organism isolated at the time of surgery was E. coli.We studied the spectrum of microbes at the time of laparotomy/laparoscopy to help us to know the emerging trends in microbiological spectrum and the sensitivity pattern in this medical college hospital. Objective: To study the microbial spectrum and sensitivity pattern in patients with intra abdominal pathology requiring surgical interventions. Methodology: After ethical committee approval was obtained, data for this retrospective study, with a sample size of 93 cases were collected from theGeneral Surgery Records and analysed. Result: Of the 93 cases studied, E. coli dominated in 75% cases of acute appendicitis and Enterococcus was found in 16.2%. In cases of hollow viscous perforation 50% were E.coli and 15.3% were K.pneumoniae. In acute appendicitis with peritonitis 64.25% were E.coli, K.pneumoniae and Enterococcus were 21.4% each.In case of colonic malignancy 28.5% of patients were infected by E. coli followed by enterococcus with 21.4%. E.coli and K. pneumoniae were more sensitive to carbapenems, colistin and fluroquinolones, while Enterococcus was more sensitive to Linezolid. Conclusion: E. coli is the organism that predominates in intra abdominal pathology requiringsurgical intervention and the common organisms are mostly sensitive to the carbapenems, linezolid , Colistin and

Microbial Spectrum of Intra-Abdominal Pathology of Patients Requiring Surgical Intervention in a Rural Teaching Hospital