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Wound healing involves number of processes which occur due to injury like coagulation, inflammation, angiogenesis, collagen deposition, epithelisation & remodelling. Steroids have been used in various situations where wounds are prone to develop. Present study was therefore undertaken to elaborate the influence of tephrosia purpurea on wound healing as well as in dexamethasone suppressed albino rats. Material & Methods: Three wound screening methods were utilized for the present study; resutured incision, dead space & excision wound screening method. Four groups consisting of 6 rats each were included in the study. Group 1 was control; group 2 was treated with tephrosia purpurea (500 mg/kg/day). Group 3 treated with dexamethasone 0.3mg/kg i.p per day & group 4 received both tephrosia purpurea (500mg/kg) & dexamethasone (0.3mg/kg) per day. Results: Tephrosia purpurea reversed dexamethasone suppressed wound healing in excision, incision & dead space wound screening methods . There was no significant improvement compared to control in incision & dead space wound screening methods. In excision wound screening method better wound contraction & epithelisation were recorded as compared to control group. Analysis & Discussion: In excision wound screening method better wound contraction & epithelisation may be due to antioxidant & antimicrobial properties of tephrosia purpurea. Reversal of suppressed wound healing by tephrosia purpurea may be because of better collagen deposition & maturation influenced by flavinoids of tephrosia purpurea. Further histological & biochemical studies are required to explain the no improvement seen in incision & dead space wound screening methods compared to control.

iosr journal of dental and medical sciences

Evaluation of Wound Healing Potential of Tephrosia Purpurea (Galega Purpurea) &amp; In Comparision with Dexamethasone Induced Antihealing Effects in Albino Rats