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A prospective, comparative study was done in the Dept. of ENT , Pravara Rural hospital , Loni to compare efficacy & tolerability of oral montelukast & nasal azelastine and to compare their effect on eosinophil count in patients of allergic rhinitis from Sept 2009 to 2011 with follow up upto 6 weeks. Total 100 patients with allergic rhinitis were enrolled in two categories, A (n=50) & B (n= 50) Both drugs were found to be highly effective & safe in treatment of allergic rhinitis as well as equally efficacious in reducing rhinorrhea . However, azelastine was found to be more effective for sneezing & nasal congestion , more efficacious in the first 3 weeks of treatment and better than montelukast for reduction of ABEC. Montelukast was found in my study to be a better drug for treatment of symptom of itchy nose . However , sedation was noted with montelukast which needs further evaluation . All in all in the present study , Azelastine unequivocally came out as the effective & safe drug in treatment of allergic rhinitis for the first 3 weeks while Montelukast can be added for patients with symptoms of itchy nose in allergic rhinitis .Montelukast stands out as the more efficacious and safe drug for later weeks of treatment of allergic rhinitis .In view of these results Azelastine is recommended for the acute treatment of allergic rhinitis and Montelukast for the late phase of treatment of allergic rhinitis.

Comparative Study of Efficacy & Tolerability of Oral Montelukast & Azelastine Nasal Spray in Allergic Rhinitis