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This casereport describes the endodontic management of a large cyst-like periradicular lesion using a combination of antibiotic drugs. A 18-yr-old girl with a large cyst-like lesion from the apices of her teeth no 11 and 21. During treatment procedure, 2.5% sodium hypochlorite solution and 2% chlorhexidine gluconate was used for irrigation and a combination of antibiotic drugs was used for the intra canal dressing. Obturation was done after2-month and periapical healing was observed after 6 months

Non- surgical healing of a Large Cyst-Like Periradicular Lesion Using local drug delivery: A Case Report