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Drug-induced nephrotoxicity is an important cause of renal failure. Aminoglycosides throughout the endocytic pathway are taken up into the epithelial cells of the renal proximal tubules and stay there for a long time, which leads to nephrotoxicity. Wistar‐ albino male rats weighing 125–150gms, are utilized for the present study.Blood samples were collected with cardiac puncture for biochemical investigations like blood urea, uric acid, creatinine, serum Na, K, Ca, determination.By using one way ANOVA the results are significant at .001. Hyaline cast formation is observed in PCT with atrophic glomeruli effecting half of the cortical region when rats treated with 80mg/kg b.w. administration of Punarnava 400mg and 800mg/kg.bw rejuvenated necrotic cells of kidney .Gentamicin must be given in the lowest effective therapeutic doses in patients with normal kidney function along with punarnava.

iosr journal of dental and medical sciences

An Experimental Study of Biochemical and Histopathological Study on Gentamycin Induced Renal Failure in Albino Rat And The Effectiveness Of Punarnava (BOERHAEVIA Diffusa) On Reversal Of Renal Damage