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Iron deficiency is the most common cause of anemia in pregnancy. The conventional iron preparations with ferrous salts showed noncompliance due to various side effects when compared to iron polymaltose complex. But the efficacy of iron polymaltose complex (IPC) in the treatment of iron deficiency anaemia (IDA) during pregnancy has not been established, and the evidence is inconclusive. The aim of this study was to compare efficacy, safety, compliance and cost-effectiveness of ferrous sulphate (FS) with IPC in antenatal women. 100 antenatal women with 14 to 20 weeks of gestation were recruited in the study, one group of 50 women were given FS and the other group of 50 women were given IPC for 6 weeks. Haemoglobin concentration (Hb), Packed cell volume(PCV),Mean Corposcular Haemoglobin concentration and serum iron were estimated before and after treatment with the above iron formulations. Compliance with pill count and safety with adverse effects monitoring in followup were noted. Statistical analysis was done with student's T test and chi square test. The improvement of haematological parameters was comparable in both groups statistically but compliance and safety were better with the IPC group when compared to FS group. IPC is a better alternative to FS as it is safe and showed more compliance.

Comparative study of efficacy and safety of Iron polymaltose complex with ferrous sulphate in antenatal women with moderate anemia