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Background And Objectives: The relationship between the synthetic hormones and premenstrual asthma has long been debated with conflicting reports regarding the effects of estrogen and progesterone. Oral contraceptives appear to have beneficial effect on lung mechanics and the proposed mechanisms vary from ventilation stimulant effect of progesterone to the collagen increasing effect of estrogen. The objective of this study was to evaluate a cross section of combined oral contraceptive pill users with healthy controls in different phases of menstrual cycle with computerized spirometry and to compare the differences. Methods: 50 users of combined oral contraceptive pill and 50 healthy controls were subjected to spirometric assessment in different phases of menstrual cycle. Student t test (2-tailed) was used to find the significance difference of PFT parameters between healthy controls and oral contraceptive user groups. Analysis of variance was used to find the significance of PFT for different phases of menstrual cycle in both the cases and controls. Results: PEF was increased throughout the menstrual cycle in combined oral contraceptive pill users suggestive of bronchodilatory effect of progesterone. Within the group, both cases and controls showed increased FVC and FEV1 suggestive of stimulation of ventilation by progesterone. Conclusion: Subjects using combined oral contraceptive pills had improved lung function than controls when evaluated with computerized spirometer.

Comparative Study of Pulmonary Function Tests in Women in Different Phases of Menstrual Cycle with and Without Contraceptive Pills