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Postoperative nausea and vomiting (PONV) not only increases patient discomfort as for some of the patients, PONV is even more distressing than post operative pain, but also adds to hospital expenditure (increased hospital stay, antiemetics) and complications related to vomiting (dehydration, electrolyte disturbances, pulmonary aspiration and rarely esophageal rupture). AIM: This study is to compare the efficacy of ondansetron hydrochloride (80µg/kg) versus granisetron hydrochloride (20µg/kg) for the control of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. METHODS: One hundred and forty consecutive adult patients scheduled for elective laparoscopic cholecystectomy were randomized into two groups: group O ondansetron group (n = 70) and group G Granisetron (n =70).Randomization was done using sealed envelope technique. A standard protocol was used in all the patients. The postoperative nausea and vomiting scoring was started immediate post-extubation. The patients were monitored in the recovery unit for the initial two hours. During that period the incidence of nausea and vomiting were recorded every 15 minutes. The nausea and vomiting scoring was continued eighth hourly for the next 24 hours. RESULTS: It was observed that 6 patients from group O and 3 patients from group G had nausea at extubation. The incidence of nausea gradually decreased over the next 24 hours, in both the groups. With regard to the incidence of vomiting, there was a gradual decrease in the incidence with time, in both our study groups. At extubation, 2 patients from group O and 1 patient from group G had one bout of vomiting. But 2 hours post extubation, none of the patients from both the groups had vomiting. On overall comparison, 37% of ondansetron hydrochloride group had nausea compared to 23% in the granisetron hydrochloride group. And 16% from the ondansetron hydrochloride group had vomiting in compasison to 3% in the granisetron hydrochloride group. Thus, based on our study we conclude that, Ondansetron (80µg/kg) is as efficacious as Granisetron (20µg/kg) for the control of postoperative nausea and vomiting in patients coming for laparoscopic cholecystectomy.

iosr journal of dental and medical sciences

Comparison of Efficacy of Ondansetron versus Granisetron for the Control of Postoperative Nausea and Vomiting In Patients Undergoing Laparoscopic Cholecystectomy