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The bacterium Helicobacter pylori (H. Pylori ) has a high prevalence of up to more than 50%, especially in developing countries and this bacteria play role in many human diseases, especially duodenal ulcers, gastric ulcers and stomach cancer. The 14 carbon- urea breath test (14C-UBT) help in diagnosis of infection, this study aims to assess the diagnostic value of Heliprobe (14C-Urea Breath Test) for the diagnosis of H. Pylori infection in patients presented with dyspepsia. A prospective study was conducted at the National Center for Early Detection of Cancer for the period extending from 18th December 2011 to 18th May 2012 and the study included (74) patients, exceeded the age of (20) years old and of both sexes who had or had not a final diagnosis of H. Pylori infection depending on histological examination (the gold standard test(GS)), were subjected to an interview questions covering aspects of social and clinical characteristics in addition to the conditions of the test. The total number of patients (74) patients, 26 (35.14%) were females and 48 (64.86%) were males, 22 (29.73%) of patients within the age group (20-30 years),most patients had gastritis, by histological examination results were 49 (66.22%) positive cases and 25 (33.78%) cases were negative, and by test results were 40 (54.1%) positive cases and 34 (45.9%) cases were negative. The proportion of test sensitivity, specificity, accuracy assessment, the positive predictive value and negative predictive value in patients were (81.63%), (100%), (87.84%), (100%) and (73.53%) respectively. Conclusions: The 14C-UBT help in the diagnosis of H. Pylori infection. Key wards: Validation, 14 Carbon-Urea Breath test, Helicobacter Pylori Infection

iosr journal of dental and medical sciences

Validation of 14 Carbon-Urea Breath Test for the Diagnosis of Helicobacter Pylori Infection in Patients Attending National Center for Early Detection of Cancer.