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Objective: To compare and evaluate the efficacy of Terminalia arjuna (aqueous extract) with digoxin on (i) Heart rate and amplitude of frogs heart in situ. (ii) Heart rate and amplitude of hypodynamic frogs heart in situ. (iii) Heart rate and amplitude of isolated perfused rabbit heart. (iv) Coronary flow of isolated perfused rabbit heart. Methods: (i) The dried bark of Terminalia arjuna was Soxhlet extracted with distilled water. (ii) The Terminalia arjuna (aqueous extract) was evaluated for its effcacy on frog and rabbit heart. (iii) Efficacy of Terminalia (aqueous extract) was compared with digoxin in reference to above mentioned parameters. Results: Terminalia arjuna (Aq.E) increased the force of contraction of cardiac muscle in frog’s heart in situ, hypodynamic frog’s heart in situ and isolated perfused rabbit heart. It also increased the coronary flow at a 400 μg dose in isolated perfused rabbit heart along with dose dependent bradycardia. However the doses required were high as compared to digoxin so the agent proved to be less potent as compared to digoxin. Conclusion: Terminalia arjuna (Aq.E) produced cardiotonic effects along with increase in the coronary flow in experimental animals where as its cholesterol lowering property has already been reported. So, it can be expected to be a good choice for CHF patients with hypercholesterolemia and requires further exploratory studies.

Experimental Evaluation of Terminalia Arjuna (Aqueous Extract) On Cardiovascular System In Comparison To Digoxin