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The exact contributions of postprandial and fasting glucose increments to overall hyperglycemia remain controversial. An observational prospective study is designed to know the relationship of the defined range of various values of glycosylated hemoglobin with fasting and postprandial glycemic status in pre-diabetics and diabetic subjects. Methods & Material: The 402 patients enrolled for this study are divided into 5 groups (Quintiles) depending upon their HbA1C levels. Results: The mean value of Fasting Plasma Glucose (FPG) and Postprandial Plasma Glucose (PPG) increases with the increasing quintile of HbA1C. The Correlation Coefficient (r- value) for the mean FPG increases with increasing HbA1C Quintiles while that of the mean PPG decreases with higher HbA1C Quintiles. Mean BMI is significantly and positively correlated with HbA1C Quintiles in Groups C, D and E. The occurrence of Diabetic Neuropathy is seen more with rising trends of HbA1C Quintiles. Conclusion: With the severity of diabetes mellitus in relation to increased HbA1C values, attention should be paid more for better control of Fasting Plasma Glucose. When the values of HbA1C are near normal or in pre- diabetic range, glycemic control should be achieved by controlling postprandial plasma glucose since here fasting plasma glucose is negatively correlated. When the values of HbA1C remain at the moderate limit due attention is needed for controlling both the fasting and the postprandial plasma glucose, judiciously.

An Observational Study on Correlation of Fasting and Postprandial Glycemic Status to various HbA1C Quintiles in Type II Diabetics.