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Acute megakaryoblastic leukemia(AML-M7) is a rare type of pediatric AML. It represents approximately 1% of all leukemias during childhood & has an incidence of 0.5% per million per year. In young children with Down syndrome, AML-M7 is the most common type of AML. There is no association reported till date in between Down syndrome & Haemoglobin E-Beta thalassaemia. In our case we got rare association of AML-M7 in a case of Down syndrome with Haemoglobin E-Beta thalassemia. This association may be incidental. But we are reporting this case for future review. Keywords - Acute Megakaryoblastic Leukemia, AML-M7, Down syndrome, Haemoglobin E-Beta thalassaemia, rare association.

Acute Megakaryoblastic Leukaemia (AML M7): Rare association of Down syndrome and Haemoglobin E-Beta Thalassaemia