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Adjuvant to local anesthetics have been tried to enhance analgesic profile. Opioids prolong analgesia but have unfavorable side effect profile. So search for non-opioid with comparable analgesic duration and minimal side effect continues. Hence our study aims to compare Buprenorphine; an opioid similar in structure to morphine but approx. 33 times more potent, to a novel drug Clonidine; an imidazoline derivative with α2-adrenergic agonistic activity. No study comparing the two drugs has been found. Settings and Design: A total of 60 patients belonging to ASA status I & II posted for orthopedic upper limb surgery were enrolled and randomly divided into three Groups of 20 each. All patients received 20 ml Bupivacaine (0.5%) in supraclavicular brachial plexus block. Group corresponding adjuvant and normal saline were added to make total solution to 40ml. VAS score and other block characteristics were observed at fixed intervals for 24 hours post operatively.“GraphPad Prism version 5.03” used for descriptive, analytic and comparative statistics. Results: Onset of sensory block was significantly delayed in clonidine group (Group BC). Analgesia lasted significantly longer in buprenorphine group(Group BB) .VAS scores were found to be better in Group BB and BC and these score was lower than Group B (bupivacaine alone)except at 24 hr. Time to first rescue analgesia and total number of doses were significantly lower in Group BB and Group BC. Incidence of nausea, vomiting and sedation were more in Group BB. Conclusions: Buprenorphine and clonidine are acceptable adjuvants.

iosr journal of dental and medical sciences

Comparative study of effects of buprenorphine or clonidine as adjuvants to local anesthetics (bupivacaine 0.25%) for supraclavicular brachial plexus block