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The Copaiba oil-resin (Copaifera sp.) is widely used in folk medicine, especially as a healing, antiinflammatory,antiseptic, to treat ulcers and skin diseases. Increased gastric emptying was observed with oilresinof Copaifera langsdorfii, highlighting those others species from the genus of Copaifera can act over thegastrointestinal tract. This study evaluated the activity of the Copaifera sp oil-resin on gastric emptying inRattus novergicus. Eighteen male rats were fasted for 24h and orally received Tween-80 and Copaiba oil-resin100 and 200 mg/kg; one hour later they all received phenol red (PR) 0.5 mg/mL. Then, the parts ofgastrointestinal tract (stomach and intestine) were analyzed. The results showed that Copaifera sp oil-resin at200 mg/kg increased the gastric emptying in Rattus novergicus.

Evaluation of oil-resin activity of Copaifera sp. on gastric emptying in Rattus<br>novergicus