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Tumor cells have an altered amino acid metabolism. They express high levels of tryptophan and L-arginine metabolizing enzymes. This leads to depletion of tryptophan and L-arginine and locally blocks T cell proliferation. Therefore, the characteristic energy metabolism of tumor cells leads to immune suppression and contributes to immune escape processes at the tumor site [1]. Excess dietary Tryptophan has shown to cause increased tumor incidence in tumorous strains of Drosophila [2]. Canton (wild type) flies were exposed to 10mM, 20mM, 30mM, 40mM and 50mM concentrations of Tryptophan. Phenotypic analysis of the exposed flies and qualitative analysis of the isolated DNA was done 24 hours and 48 hours after exposure to Tryptophan. The quality of the DNA was evaluated using Nanodrop and the DNA was subjected to Fragmentation assay to study the damage induced. Phenotypic changes observed were elongated abdomen with distinct curling and discoloration of thorax to mild orange. The isolated DNA was found to be of good quality and the fragmentation assay showed patterns of shearing. As the damage observed was not significant and the tumor induction was not observed in the experimental concentrations, tryptophan was considered non tumorigenic at the above said concentrations. However, higher concentrations of Tryptophan may induce tumor.

TUMOR INDUCTION STUDIES IN DROSOPHILA MELANOGASTER USING TRYPTOPHAN