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Respiratory infections in critically ill patients are associated with high morbidity and mortality. Patients who are mechanic ally ventilated are at high risk of acquiring respiratory tract infections due to complex interplay between the endotracheal tube, host immunity and virulence of invading bacteria. To initiate empiric antimicrobial therapy knowledge of local antimicrobial resistance patterns are essential. Material And Methods: A cross sectional study of 48 adult patients who were mechanically ventilated for various reasons in ICU of our hospital from June 2015 to May 2017 was undertaken to study profile and sensitive cha racteristics of infective organisms from endotracheal aspirate obtained after 48 hours of intubation. Results: Gram negative bacteria (83.02%) were isolated from most of the patients and Gram positive organisms were 16.98%. The most common being Acinetobacter spp. (33.96%), followed by Klebsiella pneumoniaee (32.07%) and Pseudomonas aeruginosa (15.09%). Gram positive cocci i.e. Staphylococcus aureus isolated in (16.98%) patients. Most of these gram negative organisms were susceptible to colistin and tigecycline antibiotics. Most of these gram positive organisms were susceptible to vancomycin and linezolid. Conclusion: Gram negative organisms susceptible to colistin, tigecycline and meropenem antibiotics form the predominant isolates in our critical care setu p. A local antibiogram for each hospital, based on bacteriological patterns and susceptibilities is essential to initiate empiric therapy, to prevent poor outcomes and help in framing the appropriate institutional antibiotic policy. Key wordsVentilator associated pneumonia (VAP), nosocomial infections, Endotracheal secretions.

CULTURE PROFILE AND ANTIBIOGRAM OF INFECTIVE ORGANISMS FROM ENDOTRACHEAL SECRETIONS IN MECHANICALLY VENTILATED PATIENTS OF A TERTIARY CARE CENTRE