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With every unit of blood there is 1% chance of transfusion associated problems including transfusion transmitted infections (TTI). These TTIs include hepatitis B (HBV), hepatitis C (HCV), Human Immunodeficiency Virus (HIV), syphilis, and less commonly malaria, toxoplasmosis, brucellosis, other viral infections. The process of preventing the transmission of TTIs through blood transfusion presents one of the greatest challenges of trans fusion medicine. Aim: The aim of our study was to find out the seroprevalence of infectious markers of TTIs among the blood donors. Materials and methods: A 9 years retrospective study was carried out in the blood bank of KIMS, Hubballi, Karnataka, from January 2007 to December 2015. From the donor’s blood units, 5 ml blood samples were obtained for serological testing. All the samples were screened for HIV, HCV, HBV by ELISA and RPR for syphilis. Results: A total of 80312 apparently healthy donors were analyzed for prevalence of TTIs of which 50735 (63.17%) were replacement donors and 29577 (36.83%) were voluntary donors. T he overall prevalence of TTIs was 2047/80312 (2.5 %). The overall prevalence of HIV, HBV, HCV and syphilis among donors were 283(0.35%), 1556 (1.9%), 195 (0.2%) & 13(0.01%) respectively. Conclusion: The current infectious disease pattern and trends in donor population can help in planning of future blood transfusion related health challenges. Encouraging female population as well as voluntary blood donors for blood donation will increase the number of donors and saf e donor pool. Key wordsHBV, HCV, HIV, Prevalence, TTI.

SEROPREVALENCE OF HIV, HBV, HCV AND SYPHILIS AMONG BLOOD DONORS IN KIMS BLOOD BANK HUBBALLI, KARNATAKA, A TERTIARY CARE HOSPITAL