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The objective of this study is to evaluate the physicochemical parameters of Piroxicam 20 mg Tablet brands. A comparative qualitative research study was conducted for a period of six months. A total of five different brands of active Piroxicam tablets were selected. All samples were Original Research Article Ahmed et al.; JPRI, 32(32): 82-87, 2020; Article no.JPRI.61161 83 purchased from various local markets of Larkana Sindh. These collected samples were coded as PIX01, PIX02, PIX03, PIX04 and PIX05 for minimalism. Specific physicochemical quality control lab tests included Aesthetic test, Diameter and Thickness test, Weight variation, Mechanical strength and Friability test were performed on each sample according to standards and results were compared. Packing of all samples was observed according to GMP guidelines. Data was analyzed by using statistical software SPSS 24.00. Most of the brands were within official limits of United State Pharmacopeia (USP) except brand PIX05 showing variation in hardness test, whereas two brands PIX03 and PIX05 fail in friability test as well as powder material seen inside of blisters in aesthetic test. Dissolution test for each brand of Piroxicam was performed in which PIX02, 04 and 05 failed. It was concluded that from this study after in vitro physical evaluation of various brands of Piroxicam tablets, most of the brands are being manufactured under compliance of GMP guidelines as well as specifications described under USP. Traces of powder material inside of blister in aesthetic test and unsatisfactory result in friability and hardness test in same brand indicating the deviation of GMP guidelines and USP specification which may cause the out of specification result in chemical test.

Evaluation of Physicochemical Parameters of Piroxicam 20 mg Tablets Commercially Available in District Larkana, Sindh