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Objective: The aim & objectives of this research work was to explore applicability of our previously synthesized sulfoxy amine chitosan in design, development and evaluation of transdermal drug delivery of Gliclazide. Methods: To determine the interaction between excipients used and to find out the nature of drug in the formulation, Fourier transforms infra-red spectroscopy (FTIR) and Differential Scanning Colorimetry (DSC) studies were performed. Gliclazide containing transdermal patch were formulated with help of Sulfoxy Amine Chitosan, HPMC, Penetration enhancer Dimethyl Sulfoxide and Glycerine by using solvent casting method.9 formulations prepared by using 3 full factorial designs the effect of formulation variable was studied on % Moisture Content, Folding endurance, % Cumulative drug release at 12 hrs.Formulated transdermal patches were evaluated for various parameters. Original Research Article Jadhav et al.; JPRI, 32(20): 145-161, 2020; Article no.JPRI.59419 146 Results: FTIR & DSC suggest study no drug & polymers interaction .All the prepared transdermal patches were found to be faint yellow in colored, flexible, uniform, smooth, and transparent. The weight of the transdermal patches for different type of formulations ranged between 12.00 ± 0.6 mg & 14.2 ± 0.52 mg. The thickness of the patches varied from 0.171 ± 0.0035 mm to 0.182 ± 0.0026 mm. The moisture content & water vapour transmission rate in the patches ranged from 2.33 to 4.55% & from 0.002246 to 0.003597 mg.cm/cm 2 24hrs.XRD diffractogram revealed pure Gliclazide exhibited characteristic high-intensity diffraction peaks & optimized formulation showed three peaks in 2θ= 20.6 28.7 and 38.95 with very weak intensities. Optimized batch F7 showed maximum drug release 98.41%. The folding endurance was lies in between 301 and 359. Optimization study was successfully conducted using 3 factorial designs. Conclusion: We concluded that transdermal patches Gliclazide of was successfully formulated with synthesized Sulfoxy Amine Chitosan & evaluated.

The Pharmaceutical Application of Sulfoxy Amine Chitosan in Design, Development and Evaluation of Transdermal Drug Delivery of Gliclazide