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Free radicals generated in a variety of biological systems have been implicated in mechanisms of aging and age-related pathologies. This study strategically revealed the varying levels of carbonylated proteins in 3 different tissues of 40 wistar rats of varying ages. Their ages include 2530, 45-50 and 65-70 days. The brain, heart and kidney tissue homogenates were prepared and biochemically analyzed for products of protein oxidation using 2,4-dinitrophenylhydrazones and autoantibodies against carbonylated proteins. This study revealed a direct proportional relationship between age and protein carbonylation in brain, heart and kidney tissue homogenates. The level of carbonylated proteins were significantly (P≤0.05) increased in the assayed tissues as all test groups advanced in age. Oxidative modification of proteins in brain and kidney tissues showed Original Research Article Kolawole et al.; JAMPS, 20(3): 1-5, 2019; Article no.JAMPS.48852 2 similar trend. This age-related biochemical manifestation may be as a result of increased generation of free radicals at mitochondrial level or decreased anti-oxidant defenses as living organisms advance in age.

Tissue Protein Carbonylation in Aging: A Strategic Analysis of Age-Related Protein Modification