English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: This study was undertaken to validate the haematinic potentials of the aqueous leaf extracts of Ficus exasperata (FEAE) and Telfeira occidentalis (TOAE) administered separately and to establish a possible synergistic interaction when administered concurrently to chloramphenicolinduced anaemic rats. Original Research Article Nweje et al.; IBRR, 9(3): 1-7, 2019; Article no.IBRR.48951 2 Materials and Methods: Anaemia was induced by oral administration of chloramphenicol (50 mg/kg) for 2 weeks. Five (5) nonanaemic rats and Twenty (20) anaemic rats were used in this study. The non – anaemic rats served as nonanaemic control and received 1ml dist. H2O. The 25 anaemic rats were divided into 5 groups of 5 rats each (groups 26). Group 2 served as anaemic control and received 1 ml dist. H2O, group 3 served as positive control (reference drug) and received ferrous gluconate (900 mg/kg) while groups 46 received FEAE (200 mg/kg), TOAE (200 mg/kg) and FEAE (100 mg/kg) + TOAE (100 mg/kg) respectively. Treatment was carried out once daily for 7 days after which the rats were bled for determination of PCV, Hb and WBC count. Results: Chloramphenicol induced a significant decrease PVC and Hb indicating anaemia and also resulted to a significant increase in WBC count. Aqueous leaves extracts of Ficus exasperata and Telfeira occidentalis produced significant increase in PCV and Hb with a corresponding decrease in WBC after 7 days of oral administration to anaemic rats. The antianaemic effect observed with coadministration of the extracts was however, significantly more than either of the extract administered alone. Conclusion: It can be concluded that the extracts of Ficus exasperata and Telfeira occidentalis show synergistic effect when co-administered. This could be useful in the management of

Synergistic Pharmacological Effect of Leaf Extracts of Ficus exasperata and Telfeira occidentalis on Chloramphenicol - Induced Anaemia in Wistar Rats