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Background: Ocimum gratissimum is an ethnopharmacological plant with numerous healing potentials. But there is paucity in scientific literature on its impact on the blood cells. Aim and Objective: The present study was intended to evaluate the dose and time-dependent effect of aqueous leaf extract of Ocimum gratissimum on some haematological in albino Wistar rats. Methods: Twenty four rats were randomly assigned to four equal groups. Group 1 was control, groups 2, 3 and 4 were given 450 mg/kg, 800 mg/kg and 1800 mg/kg respectively of the extract daily for 30 days. All rats had free access to water and rat chow. Results: The result showed a significantly lower RBC count in groups 3 and 4 when compared with control (p<0.05 and p<0.01 respectively). PCV was significantly lower in group 4 than control (p<0.05). Platelet count was significantly lower in group 4 than control (p<0.05) and group 2 Original Research Article Aribo et al.; EJMP, 27(2): 1-8, 2019; Article no.EJMP.14729 2 (p<0.05). A significant increase in WBC count was observed in groups 2 and 3 when compared with control (p<0.05 and p<0.01 respectively). A significant reduction in neutrophil count was observed in groups 2, 3 and 4 compared with control (p<0.05; p< 0.05 and p<0.01 respectively). There were significant increases in lymphocyte counts in groups 2, 3 and 4 when compared with control (p<0.05, p<0.01 and p<0.01 respectively). There were no significant changes in MCV, MCH and MCHC in the groups. Conclusion: In conclusion, aqueous leaf extract of Ocimum gratissimum causes reduction in RBC count, PCV, platelet count and neutrophil count but causes increases in total WBC count and lymphocyte count.

european journal of medicinal plants

Prolonged Administration of Leaf Extract of Ocimum gratissimum Reduces RBC, PCV and Platelet Count but Increases Total WBC and Lymphocyte Counts in Rats