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The Anthropocene has succeeded the 11700 years old Holocene epoch from 1945. Biological annihilation about 6 mass extinction from Holocene to present is well marked but less documented though the human dominance over bio-geo-hydro spheres has been established. IUCN is the footage of the floral/ faunal species from mammals to microorganisms. Many natural disasters, killer IAS and pandemic viruses are targeting human immune system. The 21 century virulent diseases are the HIV/AIDS, SARS, MERS, Swine flu. Corona viruses are not novice whereas COVID-19 viruses are mutation of old corona viruses. It is necessary to study the COVID-19 as one of the players of the 6 th Mass extinction. Present work envisages the 6 th mass extinction processes in India from the Holocene to present epoch. There is gradual endangering the aboriginal species, pathogens and viral species. The geospatial extinction process of 1200 years gathered from Review Article Mishra et al.; CJAST, 39(24): 13-30, 2020; Article no.CJAST.59471 14 different sources and synchronized in the India’s time frame. The present outbreak of the killer COVID-19 has triggered threat to very human existence in mid latitudes affecting 5.0 millon and fatalities 325K people over 215 countries and two ships in the globe and 101 thousand confirmed cases and 3.3K people in India (till 20.05.2020).The pandemic has paralyzed the human’s social, economic, political activities and deteriorated world economy since last four months. The viral invasion is geospatially delimiting the climate change, extreme events, economy, sociology and mass immunity of the vibrant urban demography.

The Anthropocene Dialogues on Climate Change to Human Health of Homosapiens in India